RESUMEN
Leukocytoclastic vasculitis (LCV) is a type of small vessel vasculitis, characterized by a perivascular neutrophilic inflammatory infiltrate with fibrinoid necrosis and fragmentation of nuclei ("leukocytoclasia"). Although up to half of the cases of LCV are idiopathic, infections and drugs are the most common secondary triggers for this condition. We present the case of an 88-year-old woman who developed an erythematous maculopapular rash on both thighs three days after starting gabapentin for neuropathic leg pain, without other associated symptoms. Skin biopsy was compatible with cutaneous vasculitis with a leukocytoclastic pattern. The skin lesions resolved within about 10 days after discontinuing gabapentin, supporting the diagnosis. To our knowledge, there are only four published cases of LCV secondary to gabapentin. This case highlights the importance of being alert for diagnosing drug-related cutaneous manifestations, even if the drug is used in our daily practice and vasculitis is not a common side effect, since discontinuing the suspected agent is crucial to resolve skin lesions and to avoid more serious complications.
RESUMEN
Urothelial carcinoma on a ureterocele is extremely rare in the literature, and few case reports have been reported. There are no guidelines for diagnosis and management, and current practice is extrapolated from bladder and upper urothelial tract carcinoma. We present a case from a 61-year-old man with urothelial carcinoma on a ureterocele treated with ureterocele resection, distal urethrectomy, and reimplantation on the bladder. We also review the literature concerning diagnostic approaches and management.
